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In vivo diffusion weighted 19F MRI using SF6.

Pérez-Sánchez JM, Pérez de Alejo R, Rodríguez I, Cortijo M, Peces-Barba G, Ruiz-Cabello J

Instituto de Estudios Biofuncionales. Universidad Complutense de Madrid, Madrid, Spain. iosephus@ieb.ucm.es

Diffusion weighted 19F images of rat lung in vivo using SF6 are presented. Projection-reconstruction images were acquired by filling the rat lung with a mixture of SF6 and air, during 64 successive apneas. Each apnea lasted for 6 s, the time required to perform 100 accumulations of each k-space radial phase step for the five values of the diffusion gradient (TR = 10 ms). After diffusion images were acquired, an apparent diffusion coefficient (ADC) map was generated, yielding an average value for the ADC of 2.22 x 10(-6) m2/s and SD for ADC values of 1.27 x 10(-6) m2/s. To the best of our knowledge, this is the first in vivo diffusion weighting imaging application and the first ADC map obtained using 19F MRI.

Published 25 July 2005 in Magn Reson Med, 54(2): 460-3.
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