Fluoride Research Today is a free monthly online journal that collates and summarizes the latest research about Fluoride, including details on toothpaste, water, treatment, dangers.

Evaluation of a new intraoral controlled fluoride release device.

Altinova YB, Alaçam A, Aydin A, Sanisoglu SY

Department of Pedodontics, Faculty of Dentistry, Gazi University, TR-06510 Emek, Ankara, Turkey.

The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F(-)/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface of the first maxillary molar teeth of 20 subjects (age 20-23 years). Morning and evening salivary and urinary samples were collected 5 days before the study and every day for the 1st week, then once a week for 1 month. Fluoride ion measurements were done using the microdiffusion method. The salivary and urinary fluoride concentrations were significantly raised during the treatment period (p < 0.05). Morning salivary fluoride levels were higher than evening salivary fluoride levels (p < 0.05) whereas evening urinary fluoride levels were higher than morning urinary fluoride levels (p < 0.05). The statistically significant increase in salivary fluoride levels indicates a caries-preventive role for this device.

Published 25 May 2005 in Caries Res, 39(3): 191-4.
Full-text of this article is available online (may require subscription).

© 2004-2008 Fluoride Research Today. All Rights Reserved.